Up to now, most of published CRISPR/Cas applications in plants (>97%) use an SDN-1 approach, where the traits arise from knocking-out or silencing target genes. However, there is a significant potential in gene editing approaches (SDN-2) where small, targeted modifications using homology-directed repair (HDR) can confer new characteristics to key genes.

In a recent publication, a pioneering research group from the Henan Agricultural University identified a single-nucleotide polymorphism (SNP) in the ethylene receptor gene SlEIN4 in tomato, associated with fruit firmness within a GWAS study with 266 tomato accessions. By SDN-2 targeted gene editing on SlEIN4, scientists achieved significant improvements in fruit ripening and firmness.

Up to now, most of published CRISPR/Cas applications in plants (>97%) use an SDN-1 approach, where the traits arise from knocking-out or silencing target genes. However, there is a significant potential in gene editing approaches (SDN-2) where small, targeted modifications using homology-directed repair (HDR) can confer new characteristics to key genes.

In a recent publication, a pioneering research group from the Henan Agricultural University identified a single-nucleotide polymorphism (SNP) in the ethylene receptor gene SlEIN4 in tomato, associated with fruit firmness within a GWAS study with 266 tomato accessions. By SDN-2 targeted gene editing on SlEIN4, scientists achieved significant improvements in fruit ripening and firmness.

A pioneering research group from the Henan Agricultural University

In a recent publication, a pioneering research group from the Henan Agricultural University identified a single-nucleotide polymorphism (SNP) in the ethylene receptor gene SlEIN4 in tomato, associated with fruit firmness within a GWAS study with 266 tomato accessions. By SDN-2 targeted gene editing on SlEIN4, scientists achieved significant improvements in fruit ripening and firmness.

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In a recent publication

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